Services / Nanotoxicology
NanoDiagnostic offers state of the art nanotoxicological studies for nano-based products including
- Electronic components
- Novel medical products
Exposure to materials in the nano-size range could cause significant public health problems, such as pulmonary and cardiovascular disease.
NanoDiagnostic specializes in nanomaterial characterization and cytotoxicological studies to assess the potential risk of newly engineered nanoparticles in terms of various physicochemical properties to properly assign their mechanisms or causes for toxicity both outside and within the biological environment.
Our services include but are not limited to:
X-ray photoelectron spectrometry (XPS)
Transmission electron microscopy (TEM)
XPS, is used to determine the elemental identity, chemical state, and quantity of an element by irradiating the sample with mono-energetic x-rays causing photoelectrons to be emitted from the sample surface. XPS provides invaluable information about surface layers or thin film structures in many nano-based industrial applications.
NanoDiagnostic performs imaging and analytical characterization of nanoparticles by TEM to assess nanoparticle shape, size, morphology and elemental distributions.
The zeta potential of a particle is the overall charge that the particle acquires in a particular medium, and is an indication of the repulsive forces present on the surface of the particle. This information can be used to predict the long-term stability of the product.
Fourier transform infrared spectroscopy is used to study the nature of surface adsorbents on nanoparticles. The large surface area of a nanoparticle can be modified with adsorbents to generate different properties.
Cytotoxicity can be analysed by differents features. In the literature, various studies state that the exposition of NPs to cells can affect the cellular, subcellular and genetic behavior and induce cell’s death through disruption of the plasma membrane’s integrity, mitochondrial damage and impairment of the nucleus. Exposure of the body to nanoparticles is believed to trigger an inflammatory response and provoke oxidative stress that will ultimately lead to cell death. Cytokine production and disturbance of the oxidant and anti-oxidant cellular processes are believed to be key factors in NP cytotoxicity.